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by all appearance: 从外表推断；就所知推断，就所知而言；显然，看来
labor
1. 劳动，干活：
They labour assiduously for the benefit of future generations.
他们为造福于后代而勤奋地劳动。
2. 努力(争取)；苦干：
to labour for the peace of the world
为争取世界和平而努力
to labour at a mathematical problem
努力解决一道数学题
3. 为…所苦恼；为…而吃苦头；为…迷惑，受…蒙蔽：
The couple have been labouring under housing difficulties for several years.
这对夫妇几年来一直为住房困难所困扰。
4. 费力地缓缓前进；艰难地行进：
The climbers laboured up the hillside.
爬山者吃力地缓缓爬上山坡。
take a heavy toll (on sb/sth)/take its toll (on sb/sth): to have a bad effect on sb/sth; to cause a lot of damage, deaths, suffering, etc 产生恶果，造成巨大损失
Illness had taken a heavy toll on her.
疾病对她的身体造成极大的损害。
The recession is taking its toll on the housing markets.
经济衰退使住房市场遭受着巨大的损失。
