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I ask the question
我提出一个问题
Or there's an emerging evidence
有越来越多的证据显示
That poor sleep is associated
睡眠不好会使人们
With increased reactivity to stress exposure
对压力的反应力增强
I want to look first
我首先要研究的问题是
Whether poor sleep affects stress-induced inflammation
睡眠不好是否会影响压力导致的炎症
So in response to acute stressor
为了应对短期压力
Whether poor sleep modulates those levels in circulating blood
睡眠不好是否会调节血压循环
When we are looking at pro-inflammatory cytokine
我们测量了前炎性因子的水平
Specifically IL-6
特别是IL-6的水平
One of the central ones that we measure in humans typically
这是我们测量人体时选择的主要指标
As well as the ratio of IL-6 to IL-10
我们还计算了IL-6和IL-10的比例
And then whether adiposity matters
研究肥胖症是否严重
You know, I just talked about
我刚才谈到了
How this migration seems to be important
细胞迁移为什么非常重要
And so we can look at
所以我们可以研究
Whether this varies as the function about adiposity
这种改变是否属于脂肪细胞的功能
I mentioned, you know, to many
我提到了
You might be unfamiliar with this balance
如果你们对这个问题不熟悉
The IL-6 to IL-10 balance
不熟悉IL-6和IL-10之间的平衡关系
IL-10 is an anti-inflammatory cytokine
那么IL-10是一种抗炎细胞因子
And has immunoregulatory properties
具有免疫调节的作用
To with the function of resolving that inflammation
其功能是消除炎症
On kind of as checks of balances system
所以IL-10能够保持平衡
So the ratio of IL-6 to IL-10
因此IL-6与IL-10的比例
Is thought estimate of pro-inflammatory bias
被认为用来判断炎症的程度
So the higher the ratio
这个比例越高
Potentially the worse off you are
就你的炎症系统来说
As far as your inflammation system
你的状况就越糟糕
But it has previously been shown
但前面已经证明
To be responsive to acute laboratory stress
炎症系统会对短期的实验室压力做出反应
And so that's why it is included here
所以我们这里也把这个结果包括了进来
The study was 48 postmenopausal women
这项研究对48名绝经后妇女进行了研究
