评论
打印
So it's generally associated with reduced total sleep time and we have talked about that already it’s associated with sleep fragmentation.
它通常会导致睡眠时间缩短我们刚才已经谈到这个问题了会造成睡眠不连贯
I will discuss that in a minute Low slow-wave activity this was Dr. Tiscali’s experiment.
这是我一会儿要讨论的问题慢波活动的降低这是塔莎莉博士的试验结论
With diabolic sounds coming into the room and then it has intermittent hypoxia which in itself is also deleterious to glucose tolerance.
她在卧室里发出了讨厌的声音然后是间歇性缺氧而这又会损害葡萄糖耐受力
And in this slide I'm just summarizing the findings of three different laboratory studies.
在这个图表中我对三个不同实验室的研究结论进行了总结
Two from John Hopkins and Dr. Tiscali’s study where different components of obstructive sleep apnea.
其中两项试验是约翰霍普金斯大学以及塔莎莉博士的研究他们在实验室中
Were mimicked in the laboratory in healthy young subjects so in this study Punjabi and Stamatas’s.
对健康的年轻人模拟了各种睡眠呼吸障碍的情况在这项研究中庞加比和斯坦马塔奇斯
Induced all stage sleep fragmentation not specific the slow-wave sleep and also showed the reduction of insulin sensitivity.
将睡眠的各个阶段都考虑了进来不仅仅是慢波睡眠发现他们的胰岛素敏感性都出现了下降
And then, Punjabi and others did a study in the wake subjects but 5 hours of intermittent hypoxia is compared to normoxia.
然后 庞加比和其他人对苏醒的试验参与人进行了研究对5个小时的间歇性缺氧和常氧状态进行了比较
And showing again a decrease of insulin sensitivity I want to just give you a little... You know, these changes.
发现他们的胰岛素敏感性出现了下降我给大家看看...变化程度为
Are typical 25% decrease in insulin sensitivity so for normal healthy lean person a 25% decrease of insulin sensitivity?.
胰岛素敏感性通常降低了25%所以对于正常的健康的瘦型成年人来说胰岛素敏感性每降低25%
Will occur with about a 10-kilo weight gain so it's not a small change it’s a big change.
会让他们的体重增加10公斤所以这是个不小的变化是个很大的变化
The same team at Hopkins examined then inpatients non-diabetic patients.
霍普金斯大学的同样的研究团队对住院病人进行了测试这些病人都不是糖尿病患者
Using this intravenous glucose tolerance test the impact of obstructive sleep apnea on insulin sensitivity so these are cross-sectional laboratory studies.
研究人员用静脉内葡萄糖耐受力测试方法研究了睡眠障碍对胰岛素敏感性的影响这些属于实验室进行的横断面研究
