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These are the proteins that are responsible for the control of cell proliferation, cell adhesion, cell differentiation the cell death,
这些蛋白质负责控制细胞增殖，细胞粘附，细胞分化，细胞死亡，
various aspects of the immune responseand interestingly, always the production of the 24-hydroxylase
各种免疫反应并总合成24-羟化酶，这很有趣
That's the enzyme that breaks down the vitamin D after that, so it's kind of a very quick on off switch
这是一种分解维生素D的酶，它是一种快速"开关"
as soon as vitamin D exit the genome. It induces an enzyme that destroys it, so it's actually once basically, then it breaks down
维生素D一离开基因组就会产生一种酶来将其破坏，所以只一次就没了
And then you need more vitamin D molecules if you want to do it again
之后还要继续的话，就需要更多维生素D
The striking thing and this number keeps going up from year to year is that over a thousand genes have vitamin D response elements
已发现超过一千个基因具有维生素D反应元件，这非常令人惊奇，而且数字还在增长
and some people have estimated as much as 10% of the human genome is dependent upon having adequate vitamin D
有人甚至估计 10%左右的人类基因组都依赖于适当的维生素D
So it's a terribly important ubiquitous tissue wide issue
可见这非常重要，是无处不在的问题
Now I'm going to step this through in a little bit more detail
这里我再稍微讲详细一点
Once again we're focusing on 1,25D which one to get into the cell can do what it needs to do
我们还是关注1,25D进入细胞做它该做的
but we also have recognized that 25D is present in the serum and 25D is not simply a reservoir
不过我们还意识到 25D也在血清中存在，25D不仅仅是一个"储藏库"
It's not simply an index of how much vitamin D we have in the body, although we use it for that and quite appropriately
不仅仅是体内维生素D多少的指标，当然，用它做指标确实很好
25D can be itself 1 alpha hydroxylated within the tissues themselves not just dependant upon what happens inthe kidney
25D本身可以在组织内1α-羟基化而不只取决于肾内的情况
