lose = failed in winning something.
One more wrong move and we will lose the match.
再错一步，我们就会失掉比赛。

lose = waste
Do not lose your time on something stupid like video games.
不要浪费你的时间去打游戏。

lose 走神
I lost her when she started talking about thermodynamics.
她一开始跟我讲热力学，我就走神了。

lose one's shit = 让某人抓狂
Don't make me lose my shit.
别让我发飙。

lose my cherry = 第一次做某事
Yesterday I lost my cherry playing PUBG.
昨天是我第一次玩吃鸡（绝地求生) 。

lose ground to someone or something = 在...领域失去优势
If you lose your ground in the game, don't lose your head.
如果你在这局游戏里面失去优势了，别失去理智。

lose one's head = 失去理智
Don't lose your head.
不要失去理智