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Tough medicine: GLP-1 weight-loss drugs

Glucagon-like peptide 1 (GLP-1) refers to a group of anti-obesity drugs that are typically injected – although pill-based medicines are increasingly coming to market.

Do these medications work?

Seemingly very effectively. Research from US investment bank Morgan Stanley points to a 20-30% reduction in calorie intake among anti-obesity medication patients and a notable shift in eating behaviour.

Some reports cite clinical trials that suggest these medications led to substantial weight loss, averaging 21% of participants' body weights.

Drugs in the clinical trial pipeline have shown initial data that suggests a weight-lowering profile that is comparable to bariatric surgery (high 20% weight loss).

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