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科学美国人60秒:长寿并不意味维持良好身体状态

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Living longer doesn't necessarily mean living better.

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That's the lesson from the tiny roundworm called C.elegans, long a workhorse in basic biology lab work.

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The research is in the Proceedings of the National Academy of Sciences.

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In the study, thousands of normal C. elegans competed against strains that live days or weeks longer than their brethren, because of factors like genetic mutations or very low-calorie diets.

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But a battery of tests to see how the all older worms moved or responded to stress revealed some hard truths:

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increased life span did not usually come with a prolonged period of health and strength.

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Indeed, the “good times” for each of the worms was roughly the same, regardless of their overall life span.

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In other words, the longer-living worms spent a greater proportion of their lives in a diminished state—with less mobility and stress resistance.

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Aging worms are not aging humans.

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But if the findings do extend to people, then life-extension efforts, such as calorie restriction, may not shake out to a better old age, just more years of frailty.

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With associated healthcare cost increases and quality of life decreases.

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The researchers suggest that it's time to start thinking about what they call “healthspan”—and maximizing “healthspan,”rather than just tacking on years of poor quality.

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重点单词   查看全部解释    
resistance [ri'zistəns]

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n. 抵抗力,反抗,反抗行动;阻力,电阻;反对

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stress [stres]

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n. 紧张,压力
v. 强调,着重

 
restriction [ri'strikʃən]

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n. 限制,约束

 
academy [ə'kædəmi]

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n. 学院,学术,学会

 
calorie ['kæləri]

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n. 卡,卡路里(热量单位)
=calory

 
frailty ['freilti]

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n. 脆弱,意志薄弱,虚弱,弱点

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diminished [di'miniʃt]

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adj. 减退了的;减弱的 v. 减少;削弱(dimin

 
stem [stem]

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n. 茎,干,柄,船首
vi. 起源于

 
overall [əuvə'rɔ:l]

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adj. 全部的,全体的,一切在内的
adv.

 
proportion [prə'pɔ:ʃən]

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n. 比例,均衡,部份,(复)体积,规模
vt

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