A: What's the matter, Eric? You look down in the mouth today.
B: My girlfriend said good-bye to me.
A: Why did she leave you?
B: I don't know. Maybe she just gets tired of me.
down in the mouth
exp. Visibly sad or depressed. （悲伤，压抑）
e.g George seemed a bit down in the mouth yesterday.
e.g. The bad news left her feeling really down in the mouth.
e.g. Paul looks down in the mouth because she failed in the attempt.
e.g. Why is Jane down in the mouth? She seems happy all the morning.
be tired of ：对......感到厌烦，厌倦
e.g. I' m tired of your never-ending complaints.
e.g. I sent him away because I was tired of his idle chatter.
e.g. I'm tired of your smart talk．Get off my back！
e.g. I am tired of listening to you preach at me.
e.g. All right, have it your own way I'm tired of arguing.