答案：E

解析：

Since each day has 24 hours, divide 253 by 24 to find the number of complete 24 hour intervals in 253 hours and the number of hours remaining after the 24 hour intervals have been accounted for. When 253 is divided by 24, the quotient is 10 and the remainder is 13. The 10 complete 24 hour intervals tell you that 10 days, or one full week plus 3 days, go by, bringing you to Tuesday at 4:00 p.m. The 13 additional hours take you into the next day, Wednesday. The 253 hours will end at 5:00 a.m. on Wednesday.