Treatise on Cold Pathogenic and Miscellaneous Diseases is one of the most significant books in the history of traditional Chinese medical science,written by Zhang Zhongjing (150 N 215) in the Eastern Han Dynasty, who was called the miracle-working doctor by the descendants. During his time, with war-lords fighting for their own territories, many people were infected with febrile disease .Zhang's family was no exception. He learned medicine by studying from his townsfellow Zhang Bozu, assimilating from previous medicinal lit-erature, and collecting many prescriptions elsewhere, finally writing the medical masterpiece .Shortly after its publication the book was lost during the wars that ravaged China during the period of the Three Kingdoms. It was collected by later people and com-piled into two books, namely Treatise on Cold Pathogenic Diseases , which was a discourse on how to treat the epidemic infectious diseases causing fevers prevalent during his era, and the other, Jingui Yaolue , a compendium of his clinical experiences. This medical master-piece was the greatest achievement of the medical theory since the Qin and Han Dynasties, which was applied broadly in the medical practice. It is also considered to be a monumental work for the school of febrile diseases by cold injury in traditional Chinese medicine.